最先端研究セミナー

講演者：　福原　茂朋　（日本医科大学　先端医学研究所　病態解析学部門分細胞構造学分野　教授）

演題：　Fluorescence-based live-imaging of angiogenesis and hematopoiesis in zebrafish

Abstract:

Angiogenesis is the growth of new blood vessels from the pre-existing vasculature. Under physiological conditions, angiogenesis occurs during embryonic development, wound healing and ischemic diseases. It is also implicated in the pathogenesis of various diseases, such as cancer, arthritis, diabetic retinopathy, and macular degeneration. Therefore, the understanding the mechanisms of angiogenesis is important to develop effective vascular regenerative therapy for ischemic diseases and anti-angiogenic therapy for pathological angiogenesis-associated diseases. However, it remains unclear how cellular and morphogenetic processes are coordinated to establish vascular networks during angiogenesis in vivo. To challenge this question, we have developed a fluorescence-based bio-imaging technique using zebrafish as a model animal and investigated the mechanisms underlying regulation of developmental angiogenesis. In addition, we have recently established a novel live-imaging technique for adult zebrafish and analyzed angiogenic processes during cutaneous wound healing. In this seminar, we will present our recent research on the mechanisms of developmental angiogenesis and wound-induced angiogenesis. We will also introduce our recent progress on the mechanism of specification of hemogenic endothelial cells.

References:

1. Rho S. et al. Dev. Cell 49(5): 681-696.e6 (2019).
2. Noishiki C. et al. Angiogenesis 22(2): 341-354 (2019).
3. Ando K. et al. Development 2019 Jan 25;146(2).
4. Nakajima H. et al. Dev. Cell 40 (6): 523-536 (2017).
5. Ando K. et al. Development 143：1328-1339 (2016).
6. Wakayama Y. et al. Dev. Cell 32: 109-122 (2015).
7. Kashiwada T. et al. Development 142: 497-509 (2015).

担当分野： 組織幹細胞　小川（内線：6591）

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