Cutting edge Seminar
Speaker: Yukiko GOTOH Ph.D. (Laboratory of Molecular Biology Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Title: Regulation of neural stem cell fate during development and in the adult
Date&Time: 28 Sep. (Wed.) 2016, 12:00- 13:00
Venue: Conference Room(1F), IMEG
Abstract:
One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem/progenitor cells (NPCs) attract much attention since these cells give rise to neuronal and glial cell types in a developmental-stage dependent manner with striking precision. We have previously shown that polycomb group (PcG) complex and high mobility group A (HMGA) proteins play pivotal roles in driving fate switches of NSCs during neocortical development. I would like to talk first about how these proteins are regulated and how they control the fate of NPCs in a developmental stage-dependent manner. Second, in contrast to embryonic NPCs, adult neural stem cells (NSCs) maintain their differentiation potentials for a long time to continue neurogenesis throughout life. So, I would also like to discuss the mechanisms underlying long-term maintenance of adult NSCs and the differences between embryonic NPCs and adult NSCs. Finally, I would like to talk about embryonic origin of adult NSCs.
References:
1.Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, KI., Hirabayashi, Y., and Gotoh, Y. Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells. Nat. Neurosci. 18, 657-665, 2015.
2.Kishi, Y., Fujii, Y., Hirabayashi, Y. and Gotoh, Y. HMGA proteins regulate global chromatin state and the neurogenic potential in neocortical precursor cells. Nat. Neurosci. 15, 1127-1133, 2012.
3.Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M. and Gotoh, Y. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.Neuron 63, 600-613, 2009.
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