Cutting edge Seminar

 

 

Speaker: Toshiya Endo （Professor, Faculty of Life Sciences, Kyoto Sangyo University)

Title: New views on biogenesis and quality control of mitochondria

 

Date&Time:  12 Jul. (Wed.) 2017, 12:00- 13:00
Venue: Conference Room(1F), IMEG

 

Abstract:

Mitochondria are essential for the viability of all eukaryotic cells.  They function as powerhouses for production of ATP, are crucial for the metabolism of amino acids, lipids and iron, and play a central role in apoptosis.  Defects in mitochondrial biogenesis and functions lead to severe diseases in particular of the nervous system, heart and muscles.  Since mitochondria are only generated by growth and division of preexisting mitochondria or require them as templates, mitochondrial growth relies on precise as well as efficient import of their resident proteins as well as transport and synthesis of phospholipids.  Thus, protein import and lipid transport constitute the central processes of mitochondrial biogenesis and maintenance.  In parallel, quality of mitochondrial proteins and lipids are under constant surveillance, and any defects are, when detected, cured or trigger their disposal.  I will discuss recent findings including those from my group on the molecular mechanisms of protein and lipid transport and their quality control.

 

References (or selected readings)：

1. S. Arakawa, K. Yunoki, T. Izawa, Y. Tamura, S. Nishikawa, and T. Endo (2016) Quality control of nonstop membrane proteins at the ER membrane and in the cytosol.  Sci. Rep. 6, Article number: 30795.
2. T. Shiota, K. Imai, J. Qiu, V. L. Hewitt, K. Tan, H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T Lithgow, T. Endo (2015) Molecular architecture of the active mitochondrial protein gate. Science 349, 1544-1548.
3. Y. Watanabe, Y. Tamura, S. Kawano, and T. Endo (2015) Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria. Nature Commun. 6, Article number: 7922.
4. Y. Tamura*, H. Sesaki and T. Endo (2014) Phospholipid transport via mitochondria. Traffic 15, 933-945.
5. T. Izawa, T. Tsuboi, K. Kuroha, T. Inada, S. Nishikawa, and T. Endo (2012) Role of Dom34:Hbs1 in non-stop protein clearance for normal organelle protein influx. Cell Reports 2, 447-453.

 

※　Click here for the details