講演者：　後藤　由季子（東京大学大学院薬学系研究科・薬学部　分子生物学教室　教授）

演題：　Regulation of neural stem cell fate during development and in the adult

日時： 9月28日（水） 12:00-13:00

会場： 発生医学研究所1階　カンファレンス室

Abstract:

One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem/progenitor cells (NPCs) attract much attention since these cells give rise to neuronal and glial cell types in a developmental-stage dependent manner with striking precision. We have previously shown that polycomb group (PcG) complex and high mobility group A (HMGA) proteins play pivotal roles in driving fate switches of NSCs during neocortical development. I would like to talk first about how these proteins are regulated and how they control the fate of NPCs in a developmental stage-dependent manner. Second, in contrast to embryonic NPCs, adult neural stem cells (NSCs) maintain their differentiation potentials for a long time to continue neurogenesis throughout life. So, I would also like to discuss the mechanisms underlying long-term maintenance of adult NSCs and the differences between embryonic NPCs and adult NSCs. Finally, I would like to talk about embryonic origin of adult NSCs.

Referenceｓ:

1.Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, KI., Hirabayashi, Y., and Gotoh, Y. Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells. Nat. Neurosci. 18, 657-665, 2015.

2.Kishi, Y., Fujii, Y., Hirabayashi, Y. and Gotoh, Y. HMGA proteins regulate global chromatin state and the neurogenic potential in neocortical precursor cells. Nat. Neurosci. 15, 1127-1133, 2012.

3.Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M. and Gotoh, Y. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.Neuron 63, 600-613, 2009.

詳細はこちらから

担当分野：　脳発生　嶋村健児（内線：6583）