講演者：　大野  茂男　（横浜市立大学大学院医学研究科分子細胞生物学教室　教授）

演題：　Cell Polarity: A fundamental Mechanism Shaping Cells and Tissues.

日時： 12月14日（水） 12:00-13:00
会場： 発生医学研究所1階　カンファレンス室

Abstract:
One of the fundamental questions in understanding tissue development and maintenance is how cells organize the sophisticated 3-dimensional structures each of which is closely related to their developmental and physiological roles. Epithelial cell sheets plays fundamental roles in this context. Previous studies have revealed signaling proteins involved in apicobasal cell polarity and planar cell polarity(PCP), two essential elements of 3-dimensional structure of tissues.

To address the above issues, we have been engaged in revealing the mechanism how polarity of a single cell is established and maintained, and how polarity of a single cell is linked to the structure of tissues. In the present talk, I will show you the results of our ongoing experiments related to the following issues.

1) What is the spatial cue that determines the polarity of a single cell?

2) The mechanism that determines epithelial apicobasal polarity: aPKC-PAR cassette.

3) Is there any conserved mechanism governing the polarity of a single cell?

4) How the aPKC-PAR cassette linked to cell fates?

5) How the aPKC-PAR cassette linked to planar cell polarity?

References:
1. Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, Yamashita A, Ohno S: aPKClambda maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. J Biochem,156(2):115-28, 2014.

2. Yoshihama Y, Chida K, Ohno S: The KIBRA-aPKC Connection: A Potential Regulator of Membrane Trafficking and Cell Polarity, Communicative & Integrative Biology, 5(2): 1-6, 2012.
3. Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S-I, Ohno S, Chida K: KIBRA Suppresses Apical Exocytosis through Inhibition of aPKC Kinase Activity in Epithelial Cells. Current Biol, 21, 705-711, 2011.
4. Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S: ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol, 20(15): 1408-1414, 2010.
5. Suzuki A and Ohno S: The PAR-aPKC system: lessons in polarity. J Cell Science, 119: 979-987, 2006.

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担当分野：IRCMS馬場理也（内線： 6836）