最先端研究セミナー
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講演者： 金田 篤志 （千葉大学大学院医学研究院 分子腫瘍学 教授）
演題： Virus rewires chromatin structures and enhancers of host cells to induce tumorigenesis
日時： 2021年2月17日（水）12:00-13:00
会場： Zoom開催。URLはMoodleの「HIGO最先端セミナー」にてご確認ください。
Abstract:
Gastric cancer (GC) is stratified into several molecular subtypes. A subset of GC associated with Epstein-Barr virus (EBV) infection exhibits a unique epigenotype, including the most extensive DNA hypermethylation pattern in the all human malignancies. EBV infection itself was shown to cause DNA methylation induction in >3,000 promoter CpG islands, resulting in inactivation of tumor suppressor genes e.g. p16 and SHP1. Compirehensive analysis of 3D chromatin topologies by Hi-C revealed unique compartment changes in EBV GC. Episomal EBV DNA interacting human genome remodels chromatin topology, converting a part of H3K9me3(+) heterochromatin to H3K4me1(+)/H3K27ac(+) euchromatin, and unleashing latent enhancers to engage and activate neighboring GC-related genes. Viral genome thus alters host epigenetic landscapes by a new mechanism “enhancer infestation”, suggesting importance of virus as a driver of epigenetic tumorigenesis.
Key publications:
1. Nat Genet. 52(9):919-930, 2020
2. J Pathol. 242(4):391-399, 2017
3. Nat Microbiol. 1:16026, 2016
4. Cancer Res. 71(23):7187-97, 201
担当分野：ゲノム神経 塩田（内線：6633）
※ 詳細はこちらから
