最先端研究セミナー
講演者： 山口 良文（北海道大学 低温科学研究所 冬眠代謝生理発達分野 教授）
演題： A food-storing facultative hibernator Syrian hamster as a model animal to comprehend the mysteries of mammalian hibernation from genetic and physiological aspects
日時： 2022年4月27日（水）12:00-13:00
Abstract:
Hibernation is an adaptive strategy that allows animals to persist in environments with seasonal or unpredictable decreases in food availability. Despite long history of hibernation research, little is known about the genetic and molecular mechanisms of mammalian hibernation. This is possibly due to the limitation that few appropriate experimental methodologies are available to provide empirical evidence for the causal relationship between factors (genes, molecules, and neural circuits) and phenomena. However, the situation has been changed by recent technical advances in the experimental biology field. We are studying mechanisms of hibernation in the Syrian hamster, a food-storing facultative hibernator that can hibernate when exposed to a prolonged winter-like short-day photoperiod and cold ambient temperature in a laboratory environment. In this seminar, I will briefly summarize the background of mammalian hibernation and talk about our recent approaches to the mysteries of mammalian hibernation, including seasonal body remodeling and cold tolerance, from genetic and physiological aspects.
References:
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Chayama Y, Ando L, Sato Y, Shigenobu S, Anegawa D, Fujimoto T, Taii H, Tamura Y, Miura M, Yamaguchi Y. Front Physiol. 2019 Jan 28;9:1973. doi: 10.3389/fphys.2018.01973.
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