最先端研究セミナー

 

講演者：　港　雄介　（藤田医科大学感染症研究センター 感染症創薬研究部門  准教授）

演題：  Introducing our strategy to characterize the mechanisms of antimicrobial drug synergy and antagonism.

 

 

日時： 2025年2月5日（水）12：00- 13：00

開催場所：発生医学研究所1階　カンファレンス室
※　ZOOMミーティングのURLはMoodleの「HIGO最先端セミナー」にてご確認ください。
https://md.kumamoto-u.ac.jp/course/view.php?id=114380

 

Abstract:

Some antimicrobial drugs are more effective than expected when combined (synergy), while others are less effective (antagonism). Combining synergistic antimicrobial drugs could potentially prevent the emergence of drug-resistant bacteria, and side effects could be reduced because antimicrobial drugs can be prescribed at lower doses. However, the mechanisms by which antimicrobial drugs exhibit synergy and antagonism are not fully understood. Thus, it is difficult to identify new antimicrobial drugs that synergize with existing ones. We previously revealed the mechanism of synergy between the two antimicrobial drugs, sulfamethoxazole and trimethoprim (1). In this presentation, I will present our research strategy for characterizing the mechanisms of antimicrobial drug synergy and antagonism.

 

Reference:

1. Minato Y, Dawadi S, Kordus SL, Sivanandam A, Aldrich CC, Baughn AD.

Mutual Potentiation Drives Synergy between Trimethoprim and Sulfamethoxazole. Nature communications. 9:1003, 2018.

 

 

担当分野：　微生物学講座 澤 （5320)