最先端研究セミナー

 

講演者：前澤　創（東京理科大学 創域理工学部 生命生物科学科 教授）

演題：Epigenetic regulation and alteration in mouse spermatogenesis

 

日時：2025年5月7日（水）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=120331

 

 

Abstract:

Germ cells are responsible for transmitting genetic information across generations through their differentiation into sperm or oocytes and reacquisition of totipotency after fertilization. This unique function requires the establishment of specialized epigenomic landscapes that regulate both germ cell differentiation and the activation of developmental gene programs.

Using the mouse model, we have investigated gene regulatory mechanisms during spermatogenesis and sought to elucidate the formation of germline-specific epigenomic features. Spermatogenesis involves a stepwise progression from undifferentiated spermatogonia through meiotic spermatocytes to haploid spermatids and mature sperm. This process is accompanied by large-scale, stage-specific shifts in gene expression, governed by dynamic epigenetic and chromatin structural changes. Importantly, some of the epigenetic marks established during spermatogenesis persist in sperm and may be transmitted to the next generation. Recent studies indicate that environmental factors such as aging and nutritional or psychological stress can alter the sperm epigenome, with potential intergenerational effects.

In this seminar, we will discuss our recent findings on the mechanisms of epigenomic regulation during spermatogenesis and highlight how environmental factors may induce epigenomic variability, contributing to heritable phenotypic outcomes.

 

担当分野：機能ゲノミクス分野　沖（6501)