最先端研究セミナー

講演者：津川 仁（東海大学医学部医学科生体防御学領域 　准教授）

演題：Pathogenic processes of gut commensal pathobiont

日時：2025年7月9日（水）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=120331

Abstract:

The human gastrointestinal commensal microbiota is composed predominantly of bacteria, accounting for over 99% of its constituents, with the total number of microbial cells far exceeding that of human cells. These gut commensal bacteria play a pivotal role in modulating host metabolic responses and are considered essential for maintaining human homeostasis, earning them the designation of a “second genome.” Consequently, the human host and its microbiota together constitute a highly complex biological entity, often referred to as a “superorganism.” Among the gut microbiota are certain commensal bacteria termed pathobionts, which have attracted increasing attention due to their potential contribution to various systemic diseases. Pathobionts are defined as symbiotic organisms capable of promoting pathology only under specific genetic or environmental perturbations in the host. Their pathogenicity arises from alterations in host–microbe interactions. Understanding the gut environmental conditions that trigger the transition of pathobionts from a benign to a pathogenic state is of critical importance. In our laboratory, we investigate the mechanisms by which gut commensal bacteria acquire pathogenic potential, with a particular focus on changes in host–bacteria interactions, a process known as transkingdom signaling. In this seminar, we will discuss recent insights into transkingdom signaling dynamics that underline the transformation of symbionts into pathogenic bacteria.

担当分野：微生物学講座　澤（5100)