最先端研究セミナー

招聘者： 本村 泰隆 准教授（東京理科大学生命医科学研究所・免疫アレルギー部門）

演題：Early-Life Immune Programming Shapes Allergic Susceptibility

日時：2026年2月18日（水）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=120331

Abstract：

Immunoglobulin E (IgE) is thought to have evolved as a host defense mechanism against parasitic infections, mediating rapid immune responses and parasite expulsion via activation of mast cells and basophils. While beneficial under strict regulatory control, IgE responses can become pathogenic when this balance is disrupted by environmental changes, including dietary factors, leading to allergic disease. Thus, IgE lies at a critical immunological junction between parasite defense and allergy, and understanding its dysregulation is essential to elucidate allergic disease pathogenesis.

Epidemiological studies indicate that early-life events such as infantile dermatitis, antibiotic exposure, and dietary factors are associated with sustained IgE elevation and an increased lifetime risk of allergic disease. These findings suggest that environmental influences during infancy disrupt IgE regulation and promote long-term allergic predisposition. To investigate this, we established a mouse model of environmentally induced IgE production. Consistent with human observations, infantile dermatitis induced long-lasting IgE enhancement, which exacerbated allergic pathology in adulthood, demonstrating that early-life dysregulation of IgE control increases lifelong allergic susceptibility. Moreover, we identified a contribution of innate immune mechanisms to early-life IgE induction, revealing a previously unrecognized innate immune–driven IgE pathway. Elucidation of this mechanism may enable precise control of IgE responses for both allergy prevention and parasite defense.

担当分野：細胞医学　古賀（6802)