最先端研究セミナー

招聘者： 平島 正則（新潟大学大学院医歯保健学研究科 薬理学分野 教授）

演題：Lymphatic vascular development and related diseases

日時：2026年6月17日（水）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=136783

Abstract：

Lymphatic vessels, together with blood vessels, form the body’s lifeline and play a vital role in maintaining fluid homeostasis, immune responses, lipid absorption and the removal of foreign substances. During development, lymphatic endothelial cells differentiate from venous endothelial cells to form lymph sacs, which fuse with one another to form the lymphatic network. In adults, the lymphatic network is separated from the vascular network in peripheral tissues, but it anastomoses with blood vessels near the venous angle in the neck, returning lymph collected from throughout the body to the veins. Abnormalities in the developmental process are closely linked to the development of pathological conditions and are responsible for conditions such as fetal nuchal edema and lymphatic malformations (lymphangiomas). Furthermore, if there are abnormalities in platelet activation triggered by contact with lymphatic endothelial cells, the lymphatic and vascular systems fail to separate correctly. In this seminar, focusing on these topics elucidated through the analysis of mouse models, I will introduce the molecular mechanisms of lymphangiogenesis and the pathologies arising from their abnormalities, and discuss the potential for vascular regulation based on these findings.

担当分野：組織幹細胞分野　小川（6591)