最先端研究セミナー

招聘者： 大澤 毅（東京大学 先端科学技術研究センター 准教授）

演題：Cancer metabolism within the tumor microenvironments

日時：2026年7月16日（木）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室　On site + Zoom

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=136783

Abstract：

Tumor microenvironments are critical for metabolic alteration thereby promoting tumor progression. However, how organelle dynamics controls cancer metabolism within the tumor microenvironments is not fully characterized to date. Here we demonstrate that Golgi and mitochondria dynamics may control cancer metabolism within the tumor microenvironments through comprehensive nutriomics analyses. Golgi disassembly was observed nutrient-starved cancer cells within the tumor microenvironment and stimulated golgi stress-mediated transcriptional activation. In addition, we found that acidic pH tumor microenvironment stimulated mitochondrial fission. We also found a novel mitochondrial fusion mechanism mediated by PIPs. Together, these results suggest the modulation of organelle dynamics within tumor microenvironments may become novel anti-cancer therapeutics to limit tumor progression.

担当分野：細胞医学　日野（6801）