最先端研究セミナー

招聘者：北島 智也（理化学研究所　生命機能科学研究センター　チームディレクター）

演題：Understanding and preventing age-associated chromosome segregation errors in oocytes

日時：2026年9月2日（水）　12：00-13：00

開催場所：発生医学研究所1階　カンファレンス室　On site + Zoom

※ZOOMミーティングのURLはMoodleの「S-HIGO最先端研究セミナーA、B」にてご確認ください。

https://md.kumamoto-u.ac.jp/course/view.php?id=136783

Abstract：

Egg aneuploidy is a leading cause of miscarriage and congenital disorders such as Down syndrome. It arises from chromosome segregation errors during oocyte meiosis, with incidence increasing markedly with maternal age. However, the oocyte-intrinsic features and age-associated defects that promote these errors remain incompletely understood.

Using mouse oocytes as a model, we investigate chromosome dynamics and the cellular machinery driving meiotic chromosome segregation, including the spindle and kinetochores. We have identified multiple oocyte-intrinsic factors that predispose oocytes to segregation errors, including (1) mechanisms governing spindle bipolarization and (2) regulation of kinetochore–microtubule attachments. In addition, we have found that (3) premature chromosome separation represents a major age-associated defect. In this talk, I will present our recent findings on the cell biological basis of chromosome segregation errors in oocytes and discuss emerging error-prevention strategies using synthetic tools currently under development.

担当分野：機能ゲノミクス分野　沖（6501）