Cutting edge Seminar

※  Zoom online/ Please check the URL on “HIGO Cutting-Edge Seminar” at Moodle

 

Speaker: Hiroshi Nishina (Professor, Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University)

Title：The Hippo-YAP pathway regulates 3D organ formation and homeostasis

 

Date&Time: 9 Dec.  (Wed.) 2020, 12:00- 13:00

Venue:  Zoom online/ Please check the URL on “HIGO Cutting-Edge Seminar” at Moodle

 

Summary:

The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis. Recently, we reported that YAP is essential for proper 3D body shape through regulation of cell tension by using a unique medaka fish mutant, hirame (hir). In Madin–Darby canine kidney (MDCK) epithelial cells, active YAP-transformed cells are eliminated apically when surrounded by normal cells. Furthermore, in a mosaic mouse model, active YAP-expressing damaged hepatocytes undergo apoptosis and are eliminated from the liver. Thus, YAP functions in quantitative and quality control in organogenesis.

 

References:

1. Porazinski S et al., Nature 521, 217-221 (2015).

2. Chiba T et al. Scientific Reports 6, 28383 (2016).

3. Miyamura N et al. Nature Communications 8, 16017 (2017).

4. Ishihara E and Nishina H Cancers 10(4), 122 (2018).

5. Erika Ishihara et al. Genes to Cells 23(3) 197-214 (2020).