Cutting edge Seminar

 

Speaker:  Shinpei Kawaoka  (Program-Specific Associate Professor,  Inter-Organ Communication Research Team, Department of Regeneration Science and Engineering, Institute for
Frontier Medical Sciences, Kyoto University / Associate Professor , Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer, Tohoku University)

Title:   Circadian disruption in diseases: an approach from enhancer genetics

 

 

 

Date&Time:  21 Oct.  (Thu.) 2021, 12:00-13:00

※This seminar can also be attended through ZOOM. Please check the URL on “HIGO Cutting-Edge Seminar” at Moodle.

https://md.kumamoto-u.ac.jp/course/view.php?id=90416

 

Abstract:

Coordinated circadian gene expression is critical for maintaining homeostasis. Indeed, expression rhythm of various genes is disrupted in diseases. For example, we recently reported that remote solid cancers cause circadian disruption in the liver. Yet, which altered rhythm is causal for diseases remains poorly investigated. This is largely due to the technical difficulty in manipulating rhythm of a specific gene in vivo. We tackle this problem using enhancer genetics. Enhancers are non-coding DNAs that determine spatiotemporal gene expression patterns. Deletion of an enhancer, when appropriately done, enables us to ablate a specific gene expression program in vivo. In this talk, utilizing enhancer genetics, I will demonstrate that disruption in a single oscillatory gene can be a cause of diseases. I hope that this talk will convince the audience regarding the strengths of enhancer genetics and the importance of circadian biology at the single rhythm level.

 

Reference:

1. Nat Commun 10, 2603. DOI: 10.1038/s41467-019-10525-1

2. Dis Model Mech 11. DOI: 10.1242/dmm.032383

3. Oncotarget 8, 34128-34140. DOI: 10.18632/oncotarget.16699