Cutting edge Seminar
Speaker: Yoshio Katayama （Lecturer, Hematology, Kobe University Hospital）
Title: Post-antibody Drugs: In vitro evolution for molecular-targeting helix-loop-helix peptides
Date&Time: 13 Feb. (Wed.) 2019, 12:00- 13:00
Venue: Conference Room(1F), IMEG
Abstract:
The hematopoietic organ, bone marrow (BM), is located inside the bone, and the hematopoietic and skeletal tissues contact directly in the endosteal region. We have been working on the mechanism how the BM hematopoiesis is regulated by the skeletal system. Through this activity, we found that bone biology is critically important to explain the phenomena observed in clinical hematology. I would like to introduce the relay of multiple biological factors in different classes (e.g. cytokine, neurotransmitter, lipid mediator, hormone) and cellular players (e.g. sympathetic nerve, osteoblast, osteocyte, macrophage, neutrophil) that regulates the transient and irreversible distortion of inter-organ network between hematopoietic and skeletal systems.
Reference:
Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, *Katayama Y. G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2. Blood 129, 587-597, 2017.
Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, *Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metabolism 18, 749-758, 2013.
Asada N, *Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell 6, 737-747, 2013.
Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, *Frenette PS. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124: 407-421, 2006.
