Cutting edge Seminar

 

Speaker: Tsuyoshi Osawa (Associate Professor, Research Center for Advanced Science and Technology, the University of Tokyo)

Title: Cancer metabolism within the tumor microenvironments

Date&Time: 16 July (Thu)　12：00-13：00

Venue: Conference Room(1F), IMEG, Kumamoto University  On site + Zoom

※This seminar can also be attended through ZOOM. Please check the URL on “S-HIGO Cutting-Edge Seminar A, B” at Moodle.

https://md.kumamoto-u.ac.jp/course/view.php?id=136783

 

Abstract:

Tumor microenvironments are critical for metabolic alteration thereby promoting tumor progression. However, how organelle dynamics controls cancer metabolism within the tumor microenvironments is not fully characterized to date. Here we demonstrate that Golgi and mitochondria dynamics may control cancer metabolism within the tumor microenvironments through comprehensive nutriomics analyses. Golgi disassembly was observed nutrient-starved cancer cells within the tumor microenvironment and stimulated golgi stress-mediated transcriptional activation. In addition, we found that acidic pH tumor microenvironment stimulated mitochondrial fission. We also found a novel mitochondrial fusion mechanism mediated by PIPs. Together, these results suggest the modulation of organelle dynamics within tumor microenvironments may become novel anti-cancer therapeutics to limit tumor progression.