最先端研究セミナー

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講演者：　華山  力也　（金沢大学 医学系免疫学・WPIナノ生命科学研究所　教授）え

演題：Characterization of exosomes, endogenous nano-particles

 

日時： 2020年12月16日（水）12:00-13:00

 

Abstract:

Exosomes are secreted small membrane vesicles, composed of a lipid bilayer with inserted transmembrane proteins, enclosing cytosolic components derived from the exosome-producing cells. Recently, exosomes have received much attention as messengers of intercellular communication networks, allowing the exchange of proteins and lipids between the exosome-producing cells and target cells to trigger various cellular responses. Exosomes were also shown to carry mRNAs and microRNAs inside them, raising the possibility that exosomes transfer genetic information between cells. However, it is not clear whether these processes occur under physiological conditions. Therefore, our lab is aimed at clarifying physiological and pathophysiological functions of exosomes and their secretory mechanisms.

 

Key publications:

 １．Int J Cancer. in press

２．Nano Lett. 20(9):6320-8, 2020

３．Carcinogenesis. 41(9):1238-45, 2020

４．JCI Insight. 3(8):e99680, 2018

５．EBioMedicine. 22:89-99, 2017

６．Sci Rep. 6:33935, 2016

７．Sci Rep. 5:7989, 2015

 

 

 

担当分野：微生物薬学　大槻（内線：4323）

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