最先端研究セミナー

Abstract:

In our body, cells recognize its position and roles via cell-cell communication and behave appropriately. Such cell behavior supports tissue morphogenesis and homeostasis, and its dysregulation is involved in a variety of diseases, including cancer and diabetes. We are investigating the molecular basis of cell-cell communication and behavior in animal body, using zebrafish in vivo imaging, molecular genetics, molecular and cell biology, and biochemistry.

In the first half of this seminar, I will show that “cell-cell communication-mediated abnormal cell elimination (cell competition)” is involved in proper formation of the Wnt/β-catenin signaling-mediated tissue patterning. In the second half, I will talk about the communication between healthy cells and cancerous cells in cancer development and the importance of inflammatory signaling in primary tumorigenesis. Finally, I’d like to discuss about the powerfulness of “small fish in vivo cell biology” in medical and pharmaceutical studies.

Reference:

1. Shimizu N. et al. (2014) Cell Reports 8(5): 1391-404
2. Ota S. et al. (2012) EMBO Journal 31(8): 1904-15
3. Shimizu N. et al. (2012) Developmental Biology 370(1): 71-85
4. Ishitani T et al. (2005) Nature Cell Biology 7(11): 1106-12
5. Ishitani T et al., (1999) Nature 399 (6738): 798-802

担当分野：　薬学生化学分野　土屋（内線：4359）

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