最先端研究セミナー

講演者：　片山　義雄　（神戸大学医学部附属病院　血液内科  講師）

演題：　Integrated bioflow in inter-organ communication between skeletal and hematopoietic systems

Abstract:

The hematopoietic organ, bone marrow (BM), is located inside the bone, and the hematopoietic and skeletal tissues contact directly in the endosteal region. We have been working on the mechanism how the BM hematopoiesis is regulated by the skeletal system. Through this activity, we found that bone biology is critically important to explain the phenomena observed in clinical hematology. I would like to introduce the relay of multiple biological factors in different classes (e.g. cytokine, neurotransmitter, lipid mediator, hormone) and cellular players  (e.g. sympathetic nerve, osteoblast, osteocyte, macrophage, neutrophil) that regulates the transient and irreversible distortion of inter-organ network between hematopoietic and skeletal systems.

Reference:

Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, *Katayama Y. G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE₂. Blood 129, 587-597, 2017.

Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, *Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metabolism 18, 749-758, 2013.

Asada N, *Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell 6, 737-747, 2013.

Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, *Frenette PS.  Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124: 407-421, 2006.

担当分野：IRCMS 滝澤

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