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※ Zoom開催。URLMoodleの「HIGO最先端セミナー」にてご確認ください。


講演者: 野々村 恵子 (基礎生物学研究所 初期発生研究部門 助教)

演題:Mechanosensor channel PIEZOs support function of organs ~touch sensation, control of breathing patterns, lymphatic/venous valve formation


日時: 2020年11月18日(水)12:00-13:00

会場: Zoom開催。URLMoodleの「HIGO最先端セミナー」にてご確認ください。



Mechanical stimuli applied to our body often serve as cues to trigger physiological responses. However, our understanding about physiological importance of mechanosensation has been limited partially because molecular identity of mechanosensors remained obscure until recently. PIEZO1/2 were identified in 2010 as mechanically activated cation channel. They have unique structure resembling a propeller with 3 blades and are activated when cell membrane is stretched. PIEZO2 is highly expressed in sensory neurons and functions as the key mechanotransducer for cutaneous touch sensation. In order to investigate the roles of mechanosensation among tissues/organs, I have analyzed mouse lines lacking PIEZO1/2 in specific cell type. In this talk, I’ll introduce our data about control of breathing patterns via PIEZO2-expressing sensory neurons innervating the airway and lymphatic/venous valve formation, which requires PIEZO1 in endothelial cells.



1. Nonomura K et al., Nature 541(7636): 176-181 (2017)

2. Nonomura K et al., PNAS 115(50): 12817-12822 (2018)

3. Ranade et al., Neuron 87(6): 1162-1179 (2015)


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